The effects of amyloid β-protein on the proliferation of human lung papillary adenocarcinoma

Brigham Young University-Hawaii, Laie, Hawaii; Brigham Young University, Provo, Utah; Faculty of Sciences, Brigham Young University-Hawaii, Laie, Hawaii

Alzheimer’s Disease (AD) is one of the most prevalent forms of dementia. Previous studies have shown Alzheimer’s Disease is linked with an increase in the concentration of amyloid β-protein (Aβ); recent studies indicate an infection hypothesis could explain the presence and function of amyloid β-protein as an antimicrobial peptide with additional anti-cancer properties. In this study, the anticancer properties were measured by analyzing the effects of Aβ on the in vitro cell growth of papillary adenocarcinoma from the human lung tissue line (H441). Cells were cultured in varying concentrations of Aβ protein for a period of 48 hours under standard cell culturing conditions. The results yielded a significant (p<0.0001) inhibition of cell proliferation.

Tuthill et al (2020).pdf813.88 KB